JAQJAM Consulting services are focused on advancing preclinical drug discovery programs from early hit compounds through to clinical development candidates, including process development and technology transfer for the manufacture of Phase 1 and 2 clinical supplies.
Medicinal Chemistry
- Screening library: selection, optimization and sourcing
- Hit validation: sourcing of hit compound(s) and related compound families
- De novo design: identification of novel templates and chemical matter
- Hit-to-lead optimization: increased binding affinity to target, improved selectivity over structurally related targets
- ADME optimization: modification of structural features to improve physiochemical characteristics which affect solubility, absorption, permeability, metabolic stability, hERG binding and the like
- PK/PD: design of cost effective testing strategies
- Safety Pharmacology: sourcing and interpretation of genotoxicity and receptor binding assays
- Design and synthesis of radiolabeled compound for bio-distribution and toxicology related assays
- Pre-formulation studies for pharmacology, toxicology and clinical administration
- Solid state characterization, salt screening and optimization
Bio-conjugation Chemistry
- design and optimization of bio-conjugation strategies for ADC and radio-conjugate development
Computation Chemistry
- HTS library screening (outsourced contract)
- Design of new templates using core hopping strategies
- SAR optimization using template specific virtual libraries
GMP Manufacture and Regulatory Filings
- Identification and tendering to suitable cGMP vendors
- Technology transfer documentation
- Management of process development and route scouting
- Synthesis of non-GMP toxicology lots
- Manufacture of cGMP lots
- Management of GLP analytical method development
- Drafting and updating regulatory CMC documentation: US, Canada, EU
Intellectual Property Management
- Patent search and interpretation
- Design of new chemical matter
- Drafting of biology and chemistry sections for patent filings
- Aid council in global patent prosecution responses
Industries:
JAQJAM Consulting services the medical and agricultural industries for the development of biologically active small molecule agents.
Additional synthetic chemistry optimization strategies can be applied to polymer chemistries.